Contact tracing and exposure investigation framework has helped mitigate the spread of monkeypox in the United States


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Newswise – An extensive contact tracing investigation of a patient infected with monkeypox virus (MPXV) found no secondary cases in the community or healthcare facilities. The creation of a framework to assess specific risk scenarios has facilitated application by employee occupational health personnel and application in different settings and the results have important applications to inform future prevention efforts. infections, including the administration of post-exposure prophylaxis, or PEP. The paper is published in Annals of Internal Medicine.

In May 2022, the first case of MPXV infection in the United States as part of the current global outbreak was identified. Until the case patient was identified as someone under investigation for monkeypox, he received care in many places without special precautions. As part of the public health and healthcare facility response, contact tracing and exposure investigation were conducted.

Researchers from Massachusetts General Hospital, Beth Israel Lahey Health, and the Massachusetts Department of Public Health outline a framework for contact tracing, exposure identification, risk stratification, PEP administration, and disease surveillance. the period of exposure for contacts of the index patient, including the assessment of individuals who developed symptoms that may be consistent with MPXV infection. Those at high risk were offered PEP and 3 opted to have it. Of those at intermediate risk for whom PEP was offered as part of informed clinical decision-making, 2 elected to receive PEP. No transmission was identified at the end of the 21-day surveillance period, despite the delay in recognition of monkeypox in the index patient. Public health authorities and health care facilities should consider how these results can inform revised exposure risk estimates, monitoring requirements, and recommendations for PEP.